ABSTRACT
OBJECTIVE: To prepare and characterize triptolide cubic liquidcrystal,study the rheological properties and in vitro transdermal properties. METHODS: Cubic liquid crystal (V2) was prepared by using phytantriol-carbitol-water three-component system. Using the ternary phase diagram method to optimize the target area. V2 was characterized by small-angle X-ray scattering, infrared spectroscopy and differential scanning calorimetry. Rheological properties of V2 was studied by a DHR-2 rheometer. In vitro drug release studies were conducted by using improved Franz diffusion cell method. RESULTS: SAXS is shown as double-diamond lattice cubic liquid crystal; rheological parameters are good; DSC results show V2 can be converted into a hexagonal phase at 65.5 ℃ and converted into a layered liquid crystal at 90 ℃, and the addition of the drug does not change the liquid crystal structure. In vitro transdermal cumulative permeation amount is about 1.54 times that of the gel, and the sustained release of triptolide can be as long as 48 h. CONCLUSION: The prepared triptolide liquid crystal has good appearance and suitable rheology, and its cumulative permeation amount and infiltration rate of V2 are superior to the hydrophilic gel, which provides theoretical reference for triptolide percutaneous administration.
ABSTRACT
Liquid crystalline nanoparticles are composed of a certain concentration of amphiphilic lipid self-assembly in water. The attractiveness of this formulation is linked to the nanostructural versatility, compatiblity, digestiblity and bioadhesive properties of their lipid constituents, and the capability of solubilizing and sustaining the release of amphiphilic, hydrophobic and hydrophilic drugs. Liquid crystalline nanoparticles, as a novel drug delivery system, have great promise in drug delivery. The carrier materials, preparation methods, characterization and applications of liquid crystalline nanoparticles were reviewed based on relevant articles published in recent years to provide reference for further study of liquid crystal nanoparticles.